Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1β, IL6, TNFα, and CRP)
نویسندگان
چکیده
We investigated the associations of injury severity scores (ISSs) with the mean platelet volume, the serum levels of two interleukins (IL1β and IL6), and the serum levels of tumour necrosis factor-α (TNFα) and C-reactive protein (CRP). We sought to identify biochemical parameters that could be used as components of a new biochemical parameter-based ISS system. The levels of CRP, TNFα, IL1β, and IL6 differed significantly (all p values < 0.05) between severely injured patients and controls. The mean platelet volume (MPV) did not correlate with the ISSs (p > 0.05). The TNFα and IL6 levels were useful for determining the severity of injury, and the CRP level was elevated in all trauma patients but did not correlate with the ISS. The IL1β level was higher in the study group but did not increase as the ISS increased. IL6 and TNFα levels were higher in the study group and increased as the ISS increased. We found no significant difference between the trauma group and healthy individuals in terms of MPV values. IL6 and TNFα levels can be used to assess trauma severity. However, neither the MPV nor the CRP or IL1β level is useful for this purpose.
منابع مشابه
Factors Associated with Multiple Biomarkers of Systemic Inflammation.
BACKGROUND While much is known about correlates of C-reactive protein (CRP), little is known about correlates of other inflammation biomarkers. As these measures are increasingly being used in epidemiologic studies, it is important to determine what factors affect inflammation biomarker concentrations. METHODS Using age, sex, and body mass index (BMI) adjusted linear regression, we examined 3...
متن کاملLow Serum 25‑hydroxyvitamin D levels: Predictive Value of Hematological and Inflammatory Markers in Patients with Urinary Tract Infection
Background: Low vitamin D has been linked to enhance inflammatory markers in various pathological conditions. We aimed to evaluate the urinary tract infection (UTI)-associated hematological and inflammatory markers mediated by low serum levels of 25-hydroxyvitamin D [25(OH)D]. Methods: Vitamin D level, hematological indices (Neutrophil-to-lymphocyte ratio [NLR], Monocyte-to-lymphocyte ratio [M...
متن کاملIdentification of Predictive Early Biomarkers for Sterile-SIRS after Cardiovascular Surgery
Systemic inflammatory response syndrome (SIRS) is a common complication after cardiovascular surgery that in severe cases can lead to multiple organ dysfunction syndrome and even death. We therefore set out to identify reliable early biomarkers for SIRS in a prospective small patient study for timely intervention. 21 Patients scheduled for planned cardiovascular surgery were recruited in the st...
متن کاملThe effect of caffeine supplementation and exhausting exercise on inflammatory factors in hot environments
Introduction: Caffeine, with its energizing and anti-inflammatory properties, in addition to increasing athletic performance, can reduce the exercise-induced inflammatory responses. The aim of this study was to investigate the effect of caffeine supplementation and exhausting exercise on inflammatory factors in hot environments. Methods: Thirty male athletes with a mean age of 26.6 ± 3.9 years...
متن کاملThe cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy
BACKGROUND Synovial membrane inflammation is the most common finding presenting during hip arthroscopy, and may play a role in hip pain. We sought to determine the relationships between synovial cytokine levels, hip pain, and arthroscopic findings of the hip joint. METHODS We prospectively included 33 patients who underwent arthroscopic hip surgery (34 hips). For all patients, radiographs and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2016 شماره
صفحات -
تاریخ انتشار 2016